[Answered]: Patient diagnosed with LGS has been consistently…

Patient diagnosed with LGS has been consistently on clobazam 20 mg BID for 3 years. However, seizure frequency has recently increased; therefore, provider decided to add-on the FDA-approved CBD as an adjunct. Patient tolerated this well; however, at their recent follow-up appointment they reported balance problems (ataxia). What could explain the recent emergence of the adverse effect (AE)? How do you manage this patient? A. CBD is a moderate CYP2C19 inhibitor which increased concentrations of clobazam; therefore, decrease dose of clobazam B. Clobazam is a moderate CYP2C19 inhibitor which increased concentrations of CBD; therefore, decrease dose of CBD C. A common AE of CBD is ataxia; therefore, add-on therapy should be discontinued D. CBD is an inducer of CYP2C19 which decreased concentrations of clobazam; therefore, increase dose of clobazam E. Unsure